| Rank | Title | Weekend |
|---|---|---|
| 1↑ (3) | Me Before You / 2016 | £1,453,859 |
| 2↔ (2) | Teenage Mutant Ninja Turtles: Out of the Shadows / 2016 | £840,868 |
| 3↑ (4) | Alice Through the Looking Glass / 2016 | £832,914 |
| 4↓ (1) | Warcraft / 2016 | £728,168 |
| 5↔ (5) | X-Men: Apocalypse / 2016 | £703,505 |
| 6↔ (6) | The Nice Guys / 2016 | £641,684 |
| 7 | The Boss / 2016 | £594,672 |
| 8↓ (7) | The Angry Birds Movie / 2016 | £579,144 |
| 9 | Mother's Day / 2016 | £419,532 |
| 10↓ (8) | The Jungle Book / 2016 | £412,358 |
| 11↓ (9) | Money Monster / 2016 | £179,332 |
| 12↔ (12) | Love and Friendship / 2016 | £170,296 |
| 13↓ (11) | Captain America: Civil War / 2016 | £147,485 |
| 14 | When Marnie Was There / 2014 | £99,352 |
| 15↓ (13) | Zootopia / 2016 | £87,842 |
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