| Rank | Title | Weekend |
|---|---|---|
| 1 | Me, Myself & Irene / 2000 | £1,292,512 |
| 2↓ (1) | Scary Movie / 2000 | £1,030,523 |
| 3↓ (2) | Snatch / 2000 | £811,470 |
| 4 | Space Cowboys / 2000 | £567,885 |
| 5↓ (3) | Shaft / 2000 | £565,568 |
| 6↓ (4) | O Brother, Where Art Thou? / 2000 | £456,832 |
| 7↓ (5) | The Cell / 2000 | £341,141 |
| 8↓ (6) | X-Men / 2000 | £262,698 |
| 9↔ (9) | Stuart Little / 2000 | £188,997 |
| 10↓ (8) | Chicken Run / 2000 | £185,837 |
| 11↓ (7) | Keeping the Faith / 2000 | £145,518 |
| 12↑ (14) | The Flintstones In Viva Rock Vegas / 2000 | £53,158 |
| 13↓ (11) | Fiza / 2000 | £39,376 |
| 14↓ (13) | Dancer In the Dark / 2000 | £36,511 |
| 15 ⇅ (re) | Gladiator / 2000 | £34,945 |
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