| Rank | Title | Weekend |
|---|---|---|
| 1 | The Chronicles of Narnia: The Voyage of the Dawn Treader / 2010 | £2,460,118 |
| 2↓ (1) | Harry Potter and the Deathly Hallows Part 1 / 2010 | £1,905,368 |
| 3 | The Tourist / 2010 | £1,341,143 |
| 4↓ (2) | Megamind / 2010 | £1,205,320 |
| 5↓ (3) | Unstoppable / 2010 | £406,882 |
| 6↓ (4) | Due Date / 2010 | £192,311 |
| 7↓ (5) | Monsters / 2010 | £154,743 |
| 8 | Somewhere / 2010 | £125,581 |
| 9 | No Problem / 2010 | £114,652 |
| 10↓ (6) | The American / 2010 | £109,084 |
| 11↓ (8) | Despicable Me / 2010 | £66,705 |
| 12↓ (7) | London Boulevard / 2010 | £58,572 |
| 13↓ (11) | Of Gods and Men / 2010 | £54,368 |
| 14↓ (9) | The Girl Who Kicked the Hornets Nest / 2010 | £45,457 |
| 15 ⇅ (re) | A Christmas Carol / 2009 | £32,667 |
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