| Directed by | ||
|---|---|---|
 | Greg Berlanti | |
| Starring | ||
|---|---|---|
 | Katherine Heigl | Holly Berenson |
 | Josh Duhamel | Eric Messer |
| Josh Lucas | Sam |
| Alexis Clagett | Sophie |
| Brynn Clagett | Sophie |
| Brooke Clagett | Sophie |
| Hayes MacArthur | Peter Novak |
 | Christina Hendricks | Alison Novak |
| Sarah Burns | Janine Groff |
| Jessica St. Clair | Beth |
| Brooke Liddell | Older Sophie |
| Kiley Liddell | Older Sophie |
| Britt Flatmo | Amy |
| Rob Huebel | Ted |
 | Melissa McCarthy | DeeDee |
| DeRay Davis | Lonnie |
 | Kumail Nanjiani | Simon |
| Andrew Daly | Scott |
| Bill Brochtrup | Gary |
| Will Sasso | Josh |
| Majandra Delfino | Jenna |
| Jason MacDonald | Cousin |
| Tara Ochs | Cousin's Wife |
| Wilbur Fitzgerald | Peter's Dad |
| Melissa Ponzio | Victoria (Stripper Cousin) |
| Reggie Lee | Alan Burke |
| Markus Flanagan | Chef Phillipe |
| Brooke Josephson | Liz |
| Chan Ta Rivers | CPS Worker |
| Eric Phillips | Stoned Teenager |
| Andy Buckley | George Dunn |
| L. Warren Young | Officer Young |
| Johanna Jowett | Jill |
| Jody Thompson | Worker |
| Horace Toney | Court Clerk |
| Millie Fairchild | Older Woman |
| Rob Nagle | Neighbor Dad |
| Katie Kneeland | Female Patron |
| Patricia French | Judge Gorling |
| Ron Clinton Smith | Contractor |
| Antwan Mills | Airport Security |
| Steve Nash | Self |
| Shayne Kohout | Pregnant Woman with DeeDee |
| Danielle L. Grant | Ticket Counter Lady |
| Eddie Frierson | Sports Announcer |
| Drew Allen | TSA Agent |
| Austin Behl | Groomsman |
| Marvel Bell | Funeral Party Guest |
| Tim Blanchard | Wedding Party Guest |
| Madeline Brumby | Soccer Player |
| Chevy Lamont Cofield | Store Clerk |
| Gregory Cook | Orderly |
| Keith Allen Hayes | Attorney |
| Olivia Hayes | Madison |
| Barry Hopkins | Block Party Guest |
| Heather M. Howard | Neighborhood Party Guest |
| Elizabeth Ivey | Birthday Party Guest |
| Jonathan Lewandowski Jaxson | Waiter |
| Liz Kate | Evaluation Child |
| Kate Kneeland | Female Patron |
| Amir Kovacs | Dr. Moony |
| Douglas LaPonzina | Party Guest |
| Faizon Love | Cab Driver |
| Bella Marina Marcello | Neighborhood Child |
| Marco Marcello | Carter / Neighborhood Child |
| Molly Marler | |
| Mista Martel | Hawks Fan |
| Katherine Neslund | Grocery Shopper |
| Lexi Noel | Soccer Player |
| Charlie Ping | |
| Elizabeth Pistolis | 1st Birthday Party Guest |
| Shawn Reynolds | Grocery Shopper |
| Amanda Rosario | Soccer Player |
| Alexis Renée Ruby | Middle School Student |
| Gordon J. Shenkle | Control Room Operator 2 |
| Liz Smallwood | Car Driver |
| Jean Smart | Holly's Mother |
| Gregory Marshall Smith | Control Room Tech |
| Mark Wilson | Producer |
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