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| Directed by | ||
|---|---|---|
 | Coralie Fargeat | |
| Starring | ||
|---|---|---|
 | Margaret Qualley | Sue |
 | Demi Moore | Elisabeth Sparkle |
 | Dennis Quaid | Harvey |
| Hugo Diego Garcia | Diego |
| Alexandra Papoulias Barton | Encourager |
| Oscar Lesage | Troy |
| Joseph Balderrama | Craig Silver |
| Robin Greer | The nurse |
| Tiffany Hofstetter | The Stylist |
| Gore Abrams | Oliver |
| Vincent Colombe | Suit |
 | Jiselle Henderkott | Girl |
| Oscar Salem | 2nd Assistant Director - Pump It Up Show |
| Yann Bean voice | The Substance |
| Matthew Geczy | Bob Haswell |
| Jordan Ford Silver | Assistant Director - Pump It Up Show |
| Christian Erickson | |
| Tom Morton | The Doctor |
| Gregory Defleur | Happy Birthday Person |
| Philip Schurer | Mr. Scream |
| Olivier Raynal | Alan |
| Louise Greggory | Restaurant Waitress |
| Nathan Rippy | |
| Akil Wingate | Talk Show Host |
| Viviane Bossina | Sue's Assistant |
| Daniel Knight | The Casting Director |
| Billy Bentley | Suit |
| Lucie Laffin | Une Femme |
| Matthew Luret | |
| Brett Gillen | The Lighting Designer |
| Namory Bakayoko | Silhouette |
| Pauline Sagetat | Danseuse Music-Hall |
| Axel Baille | The Photographer |
| Aurelien Lorgnier | Spectator |
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Sweden release date: 18th September 2024
Argentina release date: 19th September 2024
Australia release date: 19th September 2024
Brazil release date: 19th September 2024
Colombia release date: 19th September 2024The Substance is number 4 on the UK box office with £358.3 Thousand.
The Substance is number 9 on the US box office with $1.3 Million.
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